Live betting odds for the Arizona Cardinals at the San Francisco 49ers, Sunday, September 27, at 4:05 p.m. ET. The spread, moneyline and total below compare prices across sportsbooks and prediction markets and update automatically until kickoff.
Cardinals +5.5 | total 66.5
| Sportsbook | Cardinals spread | 49ers spread | Total | Cardinals ML | 49ers ML |
|---|
| DraftKings | +5.5 (+3300) | -5.5 (-10000) | 66.5 (+3200) | +4200 | -10000 |
| Caesars | +6.5 (-480) | -6.5 (+330) | 56.5 (+220) | +1300 | -10000 |
| Polymarket | +7.5 (-199900) | -7.5 (+199900) | 67.5 (+199900) | +199900 | -199900 |
| Kalshi | -4.5 (+4900) | +4.5 (-4900) | 68.5 (+9900) | +9900 | -19900 |
| FanDuel | +6.5 (-3000) | -6.5 (+850) | 66.5 (+1100) | +4000 | -100000 |
| BetRivers | +8.5 (-385) | -8.5 (+265) | 55.5 (-132) | +550 | -910 |
| BetMGM | +4.5 (+190) | -4.5 (-235) | 58.5 (-145) | +425 | -625 |
| Fanatics | +5.5 (+1500) | -5.5 (-8000) | 63.5 (+165) | +1300 | -3000 |
Lines from BALLDONTLIE and refreshed automatically. Numbers move, so confirm at your sportsbook before betting.
Cardinals vs. 49ers Player Props
Bam Knight RB ARI
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +10000 Fanatics | | 4 |
Devin Duvernay WR ARI
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +10000 Fanatics | | 4 |
Elijah Higgins TE ARI
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +10000 Fanatics | | 4 |
Hunter Long TE ARI
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +10000 Fanatics | | 3 |
Jacoby Brissett QB ARI
| Prop | Line | Best over | Best under | Books |
|---|
| Passing yards | 231.5 | -120 BetRivers | -120 BetRivers | 1 |
| Passing TDs | 2.5 | +220 BetRivers | -175 BetMGM | 2 |
| Anytime TD | Yes | +2800 BetRivers | | 3 |
Jalen Brooks WR ARI
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +10000 Fanatics | | 4 |
Jeremiyah Love RB ARI
| Prop | Line | Best over | Best under | Books |
|---|
| Rushing yards | 82.5 | +105 BetRivers | -110 BetMGM | 2 |
| Rush + rec yards | 100.5 | -120 BetRivers | -120 BetRivers | 1 |
| Anytime TD | Yes | +8000 Fanatics | | 3 |
Kendrick Bourne WR ARI
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +10000 Fanatics | | 4 |
Marvin Harrison Jr. WR ARI
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +10000 Fanatics | | 4 |
Michael Wilson WR ARI
| Prop | Line | Best over | Best under | Books |
|---|
| Receiving yards | 73.5 | -122 BetRivers | -117 BetRivers | 1 |
| Anytime TD | Yes | +6000 Fanatics | | 3 |
Simi Fehoko WR ARI
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +10000 Fanatics | | 4 |
Trey McBride TE ARI
| Prop | Line | Best over | Best under | Books |
|---|
| Receiving yards | 56.5 | -115 BetRivers | -124 BetRivers | 1 |
| Anytime TD | Yes | +5000 Fanatics | | 4 |
Tyler Allgeier RB ARI
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +7000 Fanatics | | 4 |
Brayden Willis TE SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +10000 Fanatics | | 2 |
Brock Purdy QB SF
| Prop | Line | Best over | Best under | Books |
|---|
| Passing yards | 278.5 | -118 BetRivers | -121 BetRivers | 1 |
| Anytime TD | Yes | +4500 Fanatics | | 4 |
Christian McCaffrey RB SF
| Prop | Line | Best over | Best under | Books |
|---|
| Rushing yards | 74.5 | -132 BetRivers | -113 BetRivers | 1 |
| Anytime TD | Yes | +1900 Fanatics | | 3 |
Deebo Samuel Sr. WR SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +12500 BetMGM | | 2 |
George Kittle TE SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +8000 Fanatics | | 3 |
Jacob Cowing WR SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +7000 Fanatics | | 4 |
Jordan Watkins WR SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +8000 Fanatics | | 4 |
Kaelon Black RB SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +3500 Fanatics | | 4 |
KhaDarel Hodge WR SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +7000 Fanatics | | 4 |
Kyle Juszczyk FB SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +6000 Fanatics | | 4 |
Luke Farrell TE SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +10000 Fanatics | | 3 |
Player props from BALLDONTLIE, refreshed every 10 minutes. Each line is the most common one across sportsbooks, with the best over and under price at that line. Anytime TD shows the best price to score. Lines move; check your sportsbook before betting. Must be 21 or older where legal. Gambling problem? Call 1-800-GAMBLER.
Reading the Lines
A negative spread marks the favorite and a positive spread the underdog. Moneylines show what a $100 bet returns on the underdog, or what it takes to win $100 on the favorite. The total is the combined points for both teams, with bets on the over or under. Prediction markets such as Kalshi and Polymarket appear alongside traditional sportsbooks, and their prices will not always match.
Must be 21 or older where legal. Gambling problem? Call 1-800-GAMBLER.
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