Oklahoma vs Michigan Odds: Spread, Moneyline & Over/Under

No. 11 Oklahoma is a 5.5 point favorite at Michigan for Saturday’s noon ET kickoff on FOX, with the total at 43.5. The Sooners opened around -5 and ticked up to -5.5 after Michigan needed a last play Hail Mary to beat Western Michigan 13-12 while Oklahoma shut out UTEP 51-0. Prediction markets have it about 68 percent Oklahoma on both Kalshi and Polymarket.

NO. 11 OKLAHOMA AT MICHIGAN · SATURDAY, SEPTEMBER 12 · NOON ET · FOXOklahoma -5.5 · Total 43.5
Market Line
Spread Oklahoma -5.5 / Michigan +5.5
Total 43.5
Opening line Oklahoma -5
Win probability (Kalshi) Oklahoma 68 percent, Michigan 32 percent
Last meeting Oklahoma 24, Michigan 13 in Norman, 2025 (line moved between -3 and -6 that week)

Lines per ESPN, CBS Sports and the Las Vegas Sun as of Friday; moneylines vary by book and are not listed. Check your book before kickoff.

Why Oklahoma Is Favored on the Road

The Sooners return most of the defense that held Michigan to 13 points last year, brought back a top 20 roster by returning production, and looked the part in a 51-0 opener. Michigan, in Kyle Whittingham’s first game, fumbled late and needed Bryce Underwood’s 47 yard heave to J.J. Buchanan on the final play to avoid a loss to a 22.5 point underdog. Michigan fell from No. 16 to unranked, and the market did not give it much home field credit.

The Case for Michigan

It is the Big House at noon, Michigan is a run first team that can shorten the game, and Oklahoma has its own offensive line issues with center Jake Maikkula, left tackle Michael Fasusi and guard Ryan Fodje all banged up. Teams tend to improve the most between their first and second games, and 5.5 points is a big number to lay against any Big Ten team in Ann Arbor. Oklahoma is 2-0 all time against Michigan, but neither win came on the road.

Our Pick

Oklahoma 24, Michigan 14. The Sooners cover and the game stays under 43.5. Full matchup notes on Oklahoma vs. Michigan: time, TV and how to watch.

Related: announcers, Ohio State vs. Texas odds, Arizona State vs. Texas A&M odds, Big Noon Kickoff in Ann Arbor.

Live Market Odds

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The Bottom Line

Oklahoma -5.5 at Michigan, total 43.5, roughly two to one on Oklahoma in the prediction markets.