Pitt is a 10.5 point favorite over Syracuse on Thursday night at Acrisure Stadium, with the total around 51. Kickoff is 7:30 p.m. ET on ESPN, it is an ACC game, and it is the 82nd meeting between the two programs, the most Syracuse has played against any opponent.
Syracuse vs. Pitt Odds
| Team | Spread | Moneyline | Total |
|---|---|---|---|
| Syracuse | +10.5 (-115) | +320 | Under 51 |
| Pitt | -10.5 (-105) | -430 | Over 51 |
Consensus numbers as of Wednesday; check your book before kickoff. Win probability models give Pitt roughly an 80 percent chance to win outright.
Series and Setup
Pitt leads the all time series 45-33-3 in a rivalry that dates to 1916. The Panthers won 11 straight from 1973 to 1983; Syracuse answered by going 16-1-1 from 1984 to 2001. This is Syracuse’s first road game of 2026, and the Orange have won their road opener five seasons in a row. The Thursday night ESPN crew is Matt Barrie, Chase Daniel and Paul Carcaterra.
The Pick
Double digit road favorites in Thursday conference games are where upsets and backdoor covers live, and Syracuse has a five year habit of winning its first road trip. We lean Syracuse +10.5 and the under, with Pitt to win outright. Full matchup detail, rosters and how to watch on the Syracuse vs. Pitt page.
Related
Syracuse vs. Pitt how to watch · Week 3 schedule · College football games today · AP Top 25
The Bottom Line
Pitt -10.5, total 51, 7:30 p.m. ET on ESPN. Pitt should win; Syracuse’s road opener streak makes the points worth a look.