The Miami Dolphins visit the San Francisco 49ers on Sunday, September 20 at 4:25 p.m. ET at Levi’s Stadium. FOX has it with Kevin Kugler and Daryl Johnston. San Francisco is home for the first time after opening the season in Australia.
Odds and Spread
Dolphins +22.5 | total 48.5
| Sportsbook | Dolphins spread | 49ers spread | Total | Dolphins ML | 49ers ML |
|---|---|---|---|---|---|
| DraftKings | +22.5 (-7400) | -22.5 (+2700) | 48.5 (+2000) | +4800 | -10000 |
| Caesars | +22.5 (-3500) | -22.5 (+950) | 41.5 (+350) | +1300 | -10000 |
| Polymarket | -20.5 (+22122) | +20.5 (-22122) | 49.5 (+199900) | +199900 | -199900 |
| Kalshi | -1.5 (+4900) | +1.5 (-4900) | 58.5 (+3233) | +9900 | -19900 |
| FanDuel | +22.5 (-100000) | -22.5 (+6000) | 48.5 (+5000) | +10000 | -100000 |
| BetRivers | +21.5 (+125) | -21.5 (-162) | 41.5 (+170) | +1400 | -10000 |
| BetMGM | +22.5 (-5000) | -22.5 (+2000) | 48.5 (+1450) | +4500 | -35000 |
| Fanatics | +22.5 (-8000) | -22.5 (+1500) | 48.5 (+1500) | +2800 | -10000 |
Lines from BALLDONTLIE and refreshed automatically. Numbers move, so confirm at your sportsbook before betting.
San Francisco is a clear home favorite after winning 27-7 in Melbourne, and Miami lost by two scores in Las Vegas. The long flight home is the one argument for the visitors here.
Start Time, TV Channel and How to Watch
| Date | Sunday, September 20, 2026 |
| Kickoff | 4:25 p.m. ET / 1:25 p.m. PT |
| TV | FOX, with Kevin Kugler and Daryl Johnston. A regional window, so coverage varies by market |
| Streaming | Fox One and the FOX Sports app with a TV provider login, or Fubo, YouTube TV, Hulu + Live TV, DirecTV Stream and Sling Blue |
| Week | NFL Week 2 |
| Stadium | Levi’s Stadium, Santa Clara, California |
How Both Teams Got Here
San Francisco beat the Rams 27-7 at the Melbourne Cricket Ground in the NFL’s first game in Australia, with the Rams as the designated home team. Miami lost 27-13 at Las Vegas.
The 49ers are the more interesting travel case. They flew to Australia and back, and this is their first actual home game of the season. That is a genuine variable even for a team that won comfortably.
What to Watch
Whether the Australia trip catches up with San Francisco. Long haul travel tends to show up a week later rather than immediately, and the 49ers have a short competitive history with this particular kind of schedule.
Miami has the simpler problem. Thirteen points in Las Vegas means the offense needs to function before anything else matters, and Levi’s is a harder place to fix it than most.
Related
49ers schedule · NFL standings · NFL scores
The Bottom Line
Dolphins at 49ers kicks off Sunday, September 20 at 4:25 p.m. ET on FOX from Levi’s Stadium. San Francisco is 1-0 after beating the Rams 27-7 in Melbourne; Miami is 0-1 after losing 27-13 at Las Vegas. The odds table above updates automatically.