The Arizona Cardinals visit the San Francisco 49ers on Sunday, September 27, at 4:05 p.m. ET on FOX in an NFC West game. San Francisco is 2 and 0 with the league’s best point differential at plus 42. Arizona is 1 and 1.
| Date | Sunday, September 27, 2026 |
| Kickoff | 4:05 p.m. ET, 1:05 p.m. PT |
| TV | FOX |
| Stadium | Levi’s Stadium, Santa Clara, California |
Points Per Game Through Two Weeks
Cardinals scored 16.5
Cardinals allowed 22.5
49ers scored 31.0
49ers allowed 10.0
San Francisco is scoring 31 and allowing 10 a game. Arizona’s point differential is minus 12, and its one win came on the road.
Current Odds
Away +8.5 | total 47.5
| Sportsbook | Away spread | Home spread | Total | Away ML | Home ML |
|---|---|---|---|---|---|
| DraftKings | +8.5 (-115) | -8.5 (-105) | 47.5 (-115) | +370 | -485 |
| Caesars | +8 (-105) | -8 (-115) | 47.5 (-117) | +325 | -410 |
| Polymarket | +7.5 (+111) | -7.5 (-111) | 47.5 (-106) | +365 | -365 |
| Kalshi | -8.5 (+102) | +8.5 (-102) | 47.5 (-102) | +365 | -365 |
| FanDuel | +8.5 (-110) | -8.5 (-110) | 47.5 (-115) | +360 | -460 |
| BetRivers | +8.5 (-109) | -8.5 (-112) | 47.5 (-113) | +335 | -455 |
| BetMGM | +8.5 (-110) | -8.5 (-108) | 48 (-108) | +340 | -450 |
| Fanatics | +8.5 (-110) | -8.5 (-110) | 48 (-110) | +310 | -400 |
Lines from BALLDONTLIE and refreshed automatically. Numbers move, so confirm at your sportsbook before betting.
Game Day Pages
Live score · 49ers inactives · Cardinals inactives · 49ers injury report · Cardinals injury report · NFC West standings