The New York Giants visit the Los Angeles Rams on Monday, September 21 at 8:15 p.m. ET, the Monday Night Football game on ESPN and ABC from SoFi Stadium. It closes out Week 2, and both teams arrive off results that surprised people.
Odds and Spread
Giants +6.5 | total 47.5
| Sportsbook | Giants spread | Rams spread | Total | Giants ML | Rams ML |
|---|---|---|---|---|---|
| DraftKings | +6.5 (-105) | -6.5 (-115) | 47.5 (-110) | +240 | -298 |
| Caesars | +6.5 (-102) | -6.5 (-118) | 47.5 (-110) | +250 | -320 |
| Polymarket | +6.5 (+106) | -6.5 (-106) | 47.5 (+102) | +277 | -277 |
| FanDuel | +6.5 (-102) | -6.5 (-120) | 47.5 (-105) | +250 | -310 |
| BetRivers | +7 (-115) | -7 (-106) | 47 (-114) | +250 | -315 |
| BetMGM | +6.5 (+100) | -6.5 (-110) | 47.5 (-108) | +240 | -300 |
| Fanatics | +6.5 (-105) | -6.5 (-115) | 47.5 (-110) | +245 | -310 |
Lines from BALLDONTLIE and refreshed automatically. Numbers move, so confirm at your sportsbook before betting.
The Rams are favored at home, though the number is tighter than it would have been two weeks ago. Los Angeles was beaten badly in its opener and New York won as an underdog, which the market has partly priced in. Check your book before kickoff.
Start Time, TV Channel and How to Watch
| Date | Monday, September 21, 2026 |
| Kickoff | 8:15 p.m. ET / 5:15 p.m. PT |
| TV | ESPN, simulcast on ABC with Joe Buck and Troy Aikman. Available free over the air through ABC in most markets. The ManningCast alternate broadcast with Peyton and Eli Manning is on ESPN2 |
| Streaming | ESPN app and ESPN Unlimited with a TV provider login, or Fubo, YouTube TV, Hulu + Live TV, DirecTV Stream and Sling Orange |
| Week | NFL Week 2, the final game of the week |
| Stadium | SoFi Stadium, Inglewood, California |
How Both Teams Got Here
The Giants opened with a 28-20 win over Dallas on Sunday night at MetLife Stadium, a division win in prime time. The Rams opened their season in Australia, losing 27-7 to San Francisco at the Melbourne Cricket Ground in the NFL’s first game in that country.
The travel matters here. Los Angeles flew to Melbourne and back, and this is its first home game after a long trip and a lopsided loss.
The Series
Los Angeles has won the last four meetings. The Giants’ most recent win in the series came in London in October 2016, and the last game was a 26 to 25 Rams win at MetLife Stadium on New Year’s Eve 2023.
What to Watch
How the Rams respond to the Melbourne result. Seven points is a bad night by any standard, and there is a reasonable argument that the trip explains part of it. A second flat performance at home would suggest otherwise.
For the Giants, whether the Dallas win travels. Beating a division rival in prime time at home is one thing; doing it on the road three time zones west on a Monday night is a different test entirely.
Related
NFL standings · NFL scores · NFL games today · Monday Night Football schedule
The Bottom Line
Giants at Rams kicks off Monday, September 21 at 8:15 p.m. ET on ESPN and ABC from SoFi Stadium. New York is 1-0 after beating Dallas 28-20; Los Angeles is 0-1 after losing 27-7 to San Francisco in Melbourne. The odds table above updates automatically.