Miami vs. Wake Forest Odds: Spread, Over/Under and How to Watch Friday Night

NO. 5 MIAMI AT WAKE FOREST · FRIDAY, SEPTEMBER 18 · 7:30 P.M. ET, ESPNMiami -21, total 56.5
Market Miami Wake Forest
Spread -21 +21
Total 56.5
2026 record 2-0 2-0
Points for, against 122, 13 76, 52

Miami is a three touchdown favorite at Allegacy Stadium in the ACC opener for both teams. The Hurricanes beat Stanford 45-6 and Florida A&M 77-7 and moved up to No. 5 in this week’s AP poll. Wake Forest opened with a 38-16 win over Akron and then won 38-36 at Purdue, the kind of shootout that explains a total in the mid 50s despite a lopsided spread.

What to Watch

  • This is Miami’s first real road test. Neither of its first two opponents was a Power Four team.
  • Wake Forest’s defense gave up 36 to Purdue. The total is built on the assumption Miami scores freely and Wake gets its share.
  • Mike Monaco, Jordan Rodgers and Dana Boyle have the ESPN call.

How to Watch

Kickoff is 7:30 p.m. ET Friday on ESPN, streaming on the ESPN app. Full details are on the Miami vs. Wake Forest matchup page. The other Friday game is Houston at Texas Tech at 8 p.m. on FOX. Odds change often; check your book before betting.