Southeast Missouri State vs. Iowa State Prediction, Odds, Spread, TV Channel and How to Watch

Saturday, September 5, 2026. Kickoff 1 p.m. ET (noon CT) on ESPN+.

Iowa State opens the Jimmy Rogers era at Jack Trice Stadium against Southeast Missouri State of the Big South-OVC. Rogers arrives after building South Dakota State into an FCS power, so he knows exactly what an FCS opponent can do to an unfocused FBS team.

WEEK 1 · EARLY AFTERNOON
Southeast Missouri State at Iowa State
Saturday, 1 p.m. ET · ESPN+ · Jack Trice Stadium
Kickoff 1 p.m. ET · noon CT · 11 a.m. MT · 10 a.m. PT
TV None. Streaming only.
Streaming ESPN+ (in the ESPN app)
Venue Jack Trice Stadium, Ames, Iowa
Line Iowa State heavily favored. Many books do not post FBS vs. FCS lines until game day.

Prediction and Odds

Iowa State should control this from the first series. The interest is in what Rogers’ offense looks like with a new quarterback and how quickly the defense, the strength of the Matt Campbell years, carries over to the new staff.

Our pick: Iowa State 41, Southeast Missouri State 10.

Why This One Matters

Iowa State goes to Iowa for the Cy-Hawk game on September 12 in a rare Kinnick primetime, so this is the only warm up. Utah visits in the Big 12 opener two weeks later.

How to Watch Without Cable

ESPN+ only. Not on cable and not in the live TV bundles. See our streaming guide.

The Bottom Line

Southeast Missouri State at Iowa State kicks off at 1 p.m. ET Saturday, September 5 on ESPN+. Iowa State comfortably in Jimmy Rogers’ debut. Result on our live scoreboard.