The Seattle Seahawks visit the Arizona Cardinals on Sunday, September 20 at 4:25 p.m. ET at State Farm Stadium in Glendale. It is on FOX, and both teams come in 1-0, which makes it the most consequential NFC West game of the early season.
Odds and Spread
Seahawks -23.5 | total 38.5
| Sportsbook | Seahawks spread | Cardinals spread | Total | Seahawks ML | Cardinals ML |
|---|---|---|---|---|---|
| DraftKings | -23.5 (-1760) | +23.5 (+1000) | 38.5 (+910) | -10000 | +6000 |
| Caesars | -23.5 (-2000) | +23.5 (+900) | 37.5 (-190) | -20000 | +2000 |
| Polymarket | +4.5 (-22122) | -4.5 (+22122) | 47.5 (+19900) | -199900 | +199900 |
| Kalshi | -33.5 (+9900) | +33.5 (-9900) | 63.5 (+3233) | -19900 | +9900 |
| FanDuel | -24.5 (-100000) | +24.5 (-100000) | 38.5 (+7500) | -100000 | +10000 |
| BetRivers | -23.5 (-113) | +23.5 (-114) | 37.5 (-250) | -10000 | +1500 |
| BetMGM | -23.5 (-5000) | +23.5 (+1600) | 37.5 (-2000) | -12500 | +2200 |
| Fanatics | -23.5 (-4000) | +23.5 (+1100) | 38.5 (+900) | -50000 | +6000 |
Lines from BALLDONTLIE and refreshed automatically. Numbers move, so confirm at your sportsbook before betting.
A division game between two 1-0 teams usually produces a tight number, and Arizona gets home field. Seattle carries the reigning Super Bowl champion label, which the market weighs even after a narrow opener. Confirm at your book before kickoff.
Start Time, TV Channel and How to Watch
| Date | Sunday, September 20, 2026 |
| Kickoff | 4:25 p.m. ET / 1:25 p.m. Arizona time. Arizona does not observe daylight saving, so it matches Pacific in September |
| TV | FOX. This is a regional window, so coverage varies by market and is strongest in Arizona and the Pacific Northwest |
| Streaming | Fox One and the FOX Sports app with a TV provider login, or Fubo, YouTube TV, Hulu + Live TV, DirecTV Stream and Sling Blue. NFL+ carries it on mobile in market |
| Week | NFL Week 2, NFC West |
| Stadium | State Farm Stadium, Glendale, Arizona |
How Both Teams Got Here
Seattle opened the season on Wednesday night, September 9, with a 13-10 win over New England at Lumen Field, the lowest scoring game of the opening slate. Arizona beat the Chargers 26-14 on the road in Week 1.
Arizona’s win is the more impressive of the two on margin, and it came away from home. Seattle needed a defensive night to get past a Patriots team that did not score a touchdown until late.
What to Watch
Whether Seattle’s offense shows up. Thirteen points in the opener is not the profile of a team defending a championship, and the defense carried that night. Arizona scored 26 on the road against a division-quality opponent.
The heat is a genuine variable in Glendale in September, though the roof and air conditioning at State Farm Stadium take most of it out of play. The larger factor is that both teams are 1-0 and the NFC West rarely produces a clean separation, so an early head to head result carries weight in the division race.
Related
NFL standings · NFL scores · NFL games today · NFL playoff odds
The Bottom Line
Seahawks at Cardinals kicks off Sunday, September 20 at 4:25 p.m. ET on FOX from State Farm Stadium, which is 1:25 p.m. local time in Arizona. Both teams are 1-0, and the winner takes early control of the NFC West. The odds table above updates automatically.