The Bills game tonight kicks off at 8:15 p.m. ET on Thursday, September 17. Buffalo hosts the Detroit Lions on Thursday Night Football in the first regular season game ever played at the new Highmark Stadium. The game streams on Prime Video nationally and airs on a local over the air station in the Buffalo market, so Western New York fans do not need an Amazon subscription.
Kickoff Time by Time Zone
| Eastern (Buffalo) | 8:15 p.m. |
| Central | 7:15 p.m. |
| Mountain | 6:15 p.m. |
| Arizona | 5:15 p.m. |
| Pacific | 5:15 p.m. |
| Toronto | 8:15 p.m. |
| UK | 1:15 a.m. Friday |
Gates and pregame festivities at the new stadium run well before kickoff; TNF Tonight, the Prime Video pregame show, starts at 7 p.m. ET.
How to Watch the Bills Tonight
| Streaming (national) | Prime Video, included with Amazon Prime |
| Local TV | WKBW Channel 7 in Buffalo; WJBK FOX 2 in Detroit |
| Phone and tablet | NFL+ (mobile only) |
| Radio | Bills Radio Network, flagship WGR 550 in Buffalo; Westwood One nationally |
| Announcers | Al Michaels, Kirk Herbstreit, Kaylee Hartung |
Odds and Injuries
Buffalo is a 4.5 point favorite with a total of 53.5. Safety Cole Bishop (knee and groin), running back Ty Johnson (hamstring) and defensive lineman T.J. Sanders (knee, illness) are questionable; Terrel Bernard was limited with a calf issue but carries no designation. Detroit is without two starting offensive linemen. Details on the injury report and odds pages.
Related
Lions vs. Bills preview · New Highmark Stadium guide · Live score · Is Cole Bishop playing · Weather
The Bottom Line
Bills vs. Lions, 8:15 p.m. ET tonight at the new Highmark Stadium, on Prime Video and local Buffalo TV. It is Buffalo’s first home game of 2026 and the first regular season game in the new building.