The Denver Broncos visit the San Francisco 49ers on Sunday, October 4, at 4:25 p.m. ET at Levi’s Stadium, on CBS or FOX. Below are the kickoff details, both teams’ live injury reports, the current betting lines and player props, all updating automatically through kickoff.
| Date |
Sunday, October 4, 2026 |
| Kickoff |
4:25 p.m. ET, 1:25 p.m. PT |
| TV |
CBS or FOX |
| Stadium |
Levi’s Stadium, Santa Clara, California |
Live Injury Report
Denver Broncos
| Player | Pos | Status | Latest | Updated |
|---|
| Jonah Coleman | RB | IR | Coleman (ankle) is being placed on injured reserve Saturday, Adam Schefter of ESPN reports. | Sep 26 |
| Frank Crum | OT | IR-R | Crum (undisclosed) was placed on injured reserve with a designation to return by the Broncos on Sunday, Aric DiLalla of the team's official site reports. | Aug 31 |
| Caleb Lohner | TE | IR-R | Lohner (lower body) was placed on injured reserve by the Broncos on Sunday with a designation to return, Aric DiLalla of the team's official website reports. | Aug 31 |
| Levelle Bailey | LB | IR | Bailey (leg) reverted to the Broncos' injured-reserve list Friday, Parker Gabriel of The Denver Post reports. | Aug 21 |
| Michael Deiter | C | IR | | Aug 19 |
| Matt Henningsen | DE | IR | | Aug 19 |
| Nick Gargiulo | G | PUP-R | Gargiulo (knee) was moved to the reserve/PUP list by the Broncos on Sunday, Aric DiLalla of the team's official site reports. | Aug 31 |
Listed for the previous game and not yet on this week's report: Tyler Badie (inactive), Dallen Bentley (inactive), Kage Casey (inactive), Sam Ehlinger (inactive), Jordan Jackson (inactive), Tyler Onyedim (inactive), Marvin Mims Jr. (questionable), RJ Harvey (questionable), J.K. Dobbins (questionable), Lil'Jordan Humphrey (inactive), Sai'vion Jones (inactive).
San Francisco 49ers
| Player | Pos | Status | Latest | Updated |
|---|
| Demarcus Robinson | WR | IR | The 49ers placed Robinson (ankle) on injured reserve Saturday. | Sep 26 |
| C.J. West | DT | IR | The 49ers placed West (undisclosed) on injured reserve Wednesday. | Sep 23 |
| De'Zhaun Stribling | WR | IR | The 49ers placed Stribling (ankle) on injured reserve Saturday. | Sep 19 |
| Jake Tonges | TE | IR | Tonges (knee) requires surgery for an MCL tear and is done for the season, Cam Inman reports. | Sep 16 |
| Alfred Collins | DT | IR | San Francisco placed Collins (knee) on injured reserve Thursday. | Sep 10 |
| Nate Hobbs | CB | IR | | Sep 8 |
| Sam Okuayinonu | DT | IR | Okuayinonu broke his foot in practice last week and is set to have surgery to repair the issue, Matt Barrows of The Athletic reports. | Sep 7 |
| Nick Martin | LB | IR | The 49ers placed Martin (hamstring) on injured reserve Tuesday, Aaron Wilson of KPRC 2 Houston reports. | Sep 1 |
| Nick Zakelj | OT | IR | Zakelj (undisclosed) was placed on the 49ers' injured reserve Sunday. | Aug 31 |
| Brett Toth | C | IR | The 49ers placed Toth (concussion) on injured reserve Sunday. | Aug 31 |
| Austen Pleasants | OT | IR-R | The 49ers placed Pleasants (knee) on injured reserve with a designation to return Sunday. | Aug 31 |
| Christian Kirk | WR | IR-R | Kirk (calf) was placed on injured reserve by the 49ers on Sunday with a designation to return. | Aug 30 |
| Mikail Kamara | DE | IR | Knee | |
| Darrick Forrest | S | IR | Undisclosed | |
| Andrew Farmer II | DE | IR | Back | |
| Ricky Pearsall | WR | IR | Knee - PCL | |
| Mykel Williams | DE | PUP-R | | Sep 8 |
| Isaac Guerendo | RB | PUP-R | Guerendo (pectoral) was placed on the reserve/PUP list Sunday, Jeremy Fowler of ESPN reports. | Aug 30 |
| Brandon Aiyuk | WR | Reserve-DNR | Head coach Kyle Shanahan said Sunday that he's not viewing Aiyuk as an option for the 49ers while the club contends with multiple injuries at receiver, Matt Barrows of The Athletic reports. | Sep 21 |
Listed for the previous game and not yet on this week's report: Tatum Bethune (inactive), Enrique Cruz Jr. (inactive), Jordan James (inactive), Ephesians Prysock (inactive), Kurtis Rourke (inactive), Jordan Watkins (inactive), Kyle Juszczyk (questionable), Khalid Kareem (questionable), George Kittle (questionable), Eddy Pineiro (questionable), Keion White (questionable), Kaelon Black (questionable), Romello Height (questionable), Jack Jones (questionable), Mike Evans (questionable), James Thompson Jr. (out), Nick Bosa (out), Dre Greenlaw (questionable), Gracen Halton (questionable), Trent Williams (questionable).
Injury data from BALLDONTLIE, refreshed every 30 minutes. Last checked Sep 29, 7:18 am ET.
Current Odds
Broncos +3 | total 46.5
| Sportsbook | Broncos spread | 49ers spread | Total | Broncos ML | 49ers ML |
|---|
| DraftKings | +3 (-115) | -3 (-105) | 46.5 (-112) | +130 | -155 |
| Caesars | +2.5 (-102) | -2.5 (-120) | 46.5 (-108) | +125 | -148 |
| Polymarket | +2.5 (+108) | -2.5 (-108) | 47.5 (+113) | +135 | -135 |
| Kalshi | +2.5 (+106) | -2.5 (-106) | 46.5 (+104) | +133 | -135 |
| FanDuel | +2.5 (-105) | -2.5 (-115) | 46.5 (-106) | +120 | -142 |
| BetRivers | +3 (-113) | -3 (-108) | 46.5 (-108) | +125 | -152 |
| BetMGM | +3 (-118) | -3 (+100) | 46.5 (-110) | +125 | -150 |
| Fanatics | +3 (-115) | -3 (-105) | 46.5 (-110) | +125 | -150 |
Lines from BALLDONTLIE and refreshed automatically. Numbers move, so confirm at your sportsbook before betting.
Player Props
Adam Trautman TE DEN
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +750 Fanatics | | 1 |
Bo Nix QB DEN
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +390 Fanatics | | 1 |
Courtland Sutton WR DEN
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +275 Fanatics | | 1 |
Dallen Bentley TE DEN
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +2500 Fanatics | | 1 |
Evan Engram TE DEN
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +390 Fanatics | | 1 |
J.K. Dobbins RB DEN
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +120 Fanatics | | 3 |
Jaylen Waddle WR DEN
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +250 Fanatics | | 3 |
Lil'Jordan Humphrey WR DEN
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +1600 Fanatics | | 1 |
Marvin Mims Jr. WR DEN
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +800 Fanatics | | 1 |
Nate Adkins TE DEN
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +1200 Fanatics | | 1 |
Pat Bryant WR DEN
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +475 Fanatics | | 1 |
RJ Harvey RB DEN
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +220 DraftKings | | 3 |
Troy Franklin WR DEN
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +575 Fanatics | | 1 |
Tyler Badie RB DEN
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +750 Fanatics | | 1 |
Brayden Willis TE SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +1700 Fanatics | | 1 |
Brock Purdy QB SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +475 Fanatics | | 1 |
Christian McCaffrey RB SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | -170 Fanatics | | 3 |
Deebo Samuel Sr. WR SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | -165 Fanatics | | 1 |
Demarcus Robinson WR SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +475 Fanatics | | 1 |
George Kittle TE SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +150 Fanatics | | 1 |
Jacob Cowing WR SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +1300 Fanatics | | 1 |
Jordan Watkins WR SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +265 Fanatics | | 1 |
Kaelon Black RB SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +300 Fanatics | | 1 |
KhaDarel Hodge WR SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +430 Fanatics | | 1 |
Kyle Juszczyk FB SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +1300 Fanatics | | 1 |
Luke Farrell TE SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +1100 Fanatics | | 1 |
Mike Evans WR SF
| Prop | Line | Best over | Best under | Books |
|---|
| Anytime TD | Yes | +180 Fanatics | | 1 |
Player props from BALLDONTLIE, refreshed every 10 minutes. Each line is the most common one across sportsbooks, with the best over and under price at that line. Anytime TD shows the best price to score. Lines move; check your sportsbook before betting. Must be 21 or older where legal. Gambling problem? Call 1-800-GAMBLER.
Game Day Pages
Live score · Week 4 odds · 49ers inactives · Broncos inactives · 49ers injury report · Broncos injury report · AFC West standings · NFC West standings
